The physical signs of addiction can include minor symptoms like mood swings, nausea, sweating and more extreme symptoms such as seizures and a lower breathing rate that can lead to an overdose, and in extreme cases, death. The long-term use of opioids can create different health issues including increased risk of heart failure and breathing problems that can cause ataxic breathing–which can cause damage to the part of the brain that controls heart and lung functions. Rehabilitation and recovery from an opioid addiction is possible but difficult. Treatment success is said to be dependent on many factors including: patient-provider rapport, social support and treatment. Around 40 to 60 per cent of people relapse in their first year of recovery.